Groundbreaking Research on OGT Enzyme & Weight Regulation
Research from Yale School of Medicine reveals that an enzyme found in the brain, known as OGT, acts as a major regulator of body weight. Removing this enzyme from neurons in the hypothalamus caused weight gain and reduced fat burning, suggesting OGT plays a vital role in controlling metabolism and energy use.
- OGT functions as a nutrient sensor within the brain.
- Helps the body decide when to burn glucose or switch to fat stores.
- Without OGT, the body fails to signal fat tissues to burn fat.
- Acts like a “metastat,” similar to a thermostat for metabolic balance.
- Maintains an individual’s natural weight set point.
- When food intake increases, OGT helps burn more calories to stabilize weight.
- Critical for metabolic homeostasis and fat utilization efficiency.
According to Professor Xiaoyong Yang, “OGT is crucial for setting the body’s weight point. It works like a thermostat, ensuring balance between food intake and fat burning.”
